Chemical Biology

化学の力を使って生命現象を解明する、あるいは制御する。こうした学問領域はChemical Biologyと呼ばれ、近年盛んになってきています。永澤研究室では、低酸素、レドックス活性金属、細胞膜挙動の解明研究を中心に、そのケミカルツールの開発と新たな生命現象解明研究を展開しています。

Chemical Biology is an emerging scientific field to understand and control biological events by “Chemical Tools”. We’re now exploring novel and unique chemical tools to study hypoxia, redox-active metal ions, and plasma membrane.

NIR-fluorescent probes for visualizing hypoxic domain

The hypoxic status of various solid tumors has been considered to be an indicator of adverse prognosis. Thus, non-invasive detection method of tumor hypoxia should be useful not only for assessment of the aggressiveness of the tumor but also for revealing carcinogenesis mechanisms. Our lab are creating new in vivo imaging tools including NIR fluorescent probes and MRI contrast agents and apply them to discover and study the hypoxia.

Bioconjugate Chemistry, 2012, 23, 324-329
Chemical Pharmaceutical Bulletin, 2012, 60, 402-407

Development of probes for ferrous ion in live cells and live animals

Iron is the most abundant transition metal ion in our body. Its biological roles are ranging from oxygen delivery, electron transport, and enzymatic reactions. However, excess Fe causes severe cell damage resulting in serious diseases such as cancer, ALS, Parkinson’s diseases, and hepatitis through abnormal production of reactive oxygen species. Therefore, iron plays important roles in healthy and diseased states of the living systems.
To study the mysterious pathological and physiological functions of iron, we are developing fluorescent probes for iron, especially Fe(II).

Chemical Sciences, 2013, 4, 1250-1256
Organic & Biomolecular Chemistry, 2014, 12, 6535-6746
Free Radical Research, 2014, 48, 990-995

Probes for study of cellular membrane dynamics and cell-penetrating devices


Pepducins are known as modulators of intracellular GPCRs. To visualize their internalization, we are developing their model compounds for studying the structural factors. We are currently studying a novel intracellular delivery system using the pepducins as a career.

Organic & Biomolecular Chemistry, 2013, 11, 3030-3037